|
GTPase-activator protein for Ras-like GTPase is a family of evolutionarily related proteins. Ras proteins are membrane-associated molecular switches that bind GTP and GDP and slowly hydrolyze GTP to GDP. This intrinsic GTPase activity of ras is stimulated by a family of proteins collectively known as 'GAP' or GTPase-activating proteins. As it is the GTP bound form of ras which is active, these proteins are said to be down-regulators of ras. The Ras GTPase-activating proteins are quite large (from 765 residues for sar1 to 3079 residues for IRA2) but share only a limited (about 250 residues) region of sequence similarity, referred to as the 'catalytic domain' or rasGAP domain. Note: There are distinctly different GAPs for the rap and rho/rac subfamilies of ras-like proteins (reviewed in reference) that do not share sequence similarity with ras GAPs. == Examples == Human genes encoding proteins containing this domain include: * DAB2IP; * GAPVD1; * IQGAP1; IQGAP2; IQGAP3; * NF1; * RASA1; RASA2; RASA3; RASA4; RASAL1; RASAL2; * SYNGAP1; 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「GTPase-activator protein for Ras-like GTPase」の詳細全文を読む スポンサード リンク
|